Myoglobin/Ck-Mb/Troponin I Combo Test – Product code: SC-0982-40
Rapid test for the diagnosis of myocardial infarction (MI) to qualitatively detect cardiac Myoglobin, CK-MB and Troponin I (c Tnl) in whole blood, serum or plasma. For professional in vitro diagnostic use only. The Myoglobin/CK-MB/Troponin I Combo Rapid Test Cassette (Whole Blood/Serum/Plasma) is a rapid immunoassay for the qualitative detection of human cardiac Myoglobin, CK-MB and Troponin I (c Tnl) in whole blood, serum o plasma and assists in the diagnosis of myocardial infarction (MI). Myoglobin (MYO), Creatinine Kinase MB (CK-MB) and cardiac Troponin I (cTnl) are proteins released into the bloodstream following heart damage. Myoglobin is a hemoprotein normally present in heart muscle and skeletal muscle with a molecular weight of 17.8 kDa. Myoglobin (MYO), Creatinine Kinase MB (CK-MB) and cardiac Troponin I (cTnl) are proteins released into the bloodstream following heart damage. Myoglobin is a hemoprotein normally present in heart muscle and skeletal muscle with a molecular weight of 17.8 kDa. When muscle cells are damaged, myoglobin is rapidly released into the blood due to its relatively small size. Myoglobin level increases measurably above the reference standard in the 2-4 hours following the heart attack, peaking after 9-12 hours and returning to the standard value in 24-36 hours.2,3 CK-MB is a enzyme also present in heart muscle, with a molecular weight of 87.0 kDa.4 Creatinine Kinase is a dimeric molecule formed by two subunits called “M” and “B” which combine to form three different isoenzymes: CK-MM , CK-BB and CK-MB. CK-MB is the creatinine kinase isoenzyme most involved in the metabolism of cardiac muscle tissues. The release of CK-MB into the blood following IM can be detected in the 3-8 hours following the onset of symptoms. It peaks in 9-30 hours and returns to standard levels in 40-72 hours. Cardiac Troponin I is a protein found in heart muscle with a molecular weight of 22.5 kDa7. Troponin I is part of a complex of three subunits that includes Troponin T and Troponin C. Together with tropomyosin, this structural complex forms the main component that regulates the activity of actomyosin Calcium-ATpase in striated skeletal muscle and cardiac. Following heart damage, Troponin I is released into the blood in the 4-6 hours following the onset of pain. The Troponin I delivery system is similar to that of CK-MB, but while CK-MB levels return to normal after 72 hours, Troponin I remains elevated for 6-10 days, thus providing a wider detection window for heart damage. The Myoglobin/CK-MB/Troponin I Combo Rapid Test Cassette (Whole Blood/Serum/Plasma) is a simple test that uses a combination of antibody-coated particles and captures reagents to qualitatively detect Myoglobin, CK-MB and Troponin I (c Human cardiac Tnl) in whole blood, serum or plasma. The minimum detection level is 50 ng/mL for Myoglobin, 5 ng/mL for CK-MB and 0.5 ng/mL for Troponin I. The Myoglobin/CK-MB/Troponin I Combo Rapid Test Cassette (Whole Blood/Serum/Plasma) is a qualitative, membrane-based immunoassay for the detection of cardiac Myoglobin, CK MB and Cardiac Troponin I (c Tnl) in whole blood, serum or plasma. The membrane is pre-coated with specific antibodies in each of the regions of the test line. During the test, the whole blood, serum or plasma sample reacts with the particle coated with specific antibodies. The compound migrates chromatically upwards on the membrane by capillary action to react with the specific reagents on the membrane and generate a colored line. The presence of this colored line in the specific region of the test line indicates a positive result, while its absence indicates a negative result. As a procedural control, a colored line always appears in the control zone to indicate that the amount of sample used is sufficient and the membrane has been soaked correctly.
Reviews
There are no reviews yet.